Jenson Mak | Vitality & Healthy Ageing Blog

Dr. Jenson Mak covers the best of living a vital and healthy life at any age.

Tag: Exercise (Page 1 of 2)

hand-apple-iphone-smartphone

The Best Health Apps 2017

As technology and education continues to revolutionize and empower human beings, there is no better time to focus on your personal health and fitness than now. The ease and flexibility of having a fitness app on your phone allows you more time and motivation to workout throughout the day and keep up with your health. Here are the top health apps you should have on your phone for optimal daily motivation.

 

Workout Trainer

This app is great for those looking to stay active throughout the day. If you get bored of the same, boring routine, then this app is for you. Workout trainer provides you with hundreds of workouts from strength training, to cardio, to yoga and relaxation. You get to pick what type of workout you’re feeling that day and which muscles you want to strengthen. This app will ensure that you’re staying physically active throughout the day with many different options for you to choose from. This is a great app to switch up your routine, while keeping track of your daily activity.

 

Yoga Studio

If you’re tired of driving back and forth to the yoga studio every morning, while traffic is far from allowing you to destress. Yoga Studio is the app for you. First of all, yoga should be relaxing, and there is nothing relaxing about paying a costly monthly fee for joining yoga studios each month. Yoga studio is a great app to use throughout your day. All you need is a relaxing, quiet space to turn your home into the same comfort as a yoga studio. The app offers a variety of virtual yoga classes from beginner to advanced practices. Save time and money by implementing this app into your lifestyle, and be on the road to a relaxing and stress free daily routine.

 

My Fitness Pal

Part of living a healthy lifestyle through diet and exercise is planning out and monitoring your daily activity and the foods you eat. My Fitness Pal is a great app for those on the go. The app allows you to scan or enter in details about any foods you eat throughout the day. It also allows you to enter in your daily physical activity, which can be linked to other apps in your phone. The app will keep track of the nutrition of your daily foods, such as calories, carbs, sodium, etc, while tracking your physical activity. You can also set goals such as weight loss, and the app will help you with a target of calories to intake daily, and exercises to practice throughout the day.

 

Sleep Cycle

One of the biggest aspects of living a healthy lifestyle is getting a good night’s sleep. Sleep Cycle is a great app to keep track of your sleeping. It works through a motion sensor in your phone and a microphone which is able to be heard when you move around in your sleep. It also has an alarm feature that will softly wake you up, allowing you to train your body to go to sleep and wake up at a consistent routine time. The key to your daily productivity is sleep, therefore this app will allow you to start the day right.

yoga-929855_960_720

5 Health Benefits of Yoga

Yoga and meditation have been studied and practiced for thousands of years. The primary idea of yoga is to find peace and happiness between yourself and your body in the outside world. Even if you consider yourself happy, the practice gives you a boost in your life through the way that you think. Yoga is a great way to enhance your health and wellness, and is an excellent practice for those looking to age well. The practice fights against stressors and allows you to find peace within your mind, while strengthening your physical body as well. Through consistent yoga practice, you can increase your health through these benefits

 

Mental Health

Yoga has a great positive effect on various mental health diseases. Yoga allows you to become one with yourself through practice, ultimately decreasing negative thoughts. The brain is able to relax and focus on one thing only: the practice. Studies have shown that consistent yoga practice has had a positive impact on patients fighting mental health struggles. It is one of the most positive homeopathic medicines available for mental diseases.

 

Muscle Strength

Yoga also comes with the benefits of a daily workout. If you’re looking to build up muscle strength, yoga is a great practice. Because you are using your own body weight, you aren’t pressured of dealing with free weights, which could be harmful if not practiced correctly. When using your own body weight, you have the ability to build the strength you need naturally through practice.

 

Increased Flexibility

Your body’s flexibility is very important when it comes to working out. When your muscles aren’t stretched before and after a workout, you risk the chance of developing an injury. Yoga allows you to increase your flexibility and loosen your muscles. Through practice, you’ll see a great difference in your typical workouts and exercises.

 

Better Breathing

Because you are focusing on your breath and your body during yoga, you practice the art of better breathing. Breathing allows you to calm your body down and receive the oxygen it needs to circulate through your blood in your body. During yoga practice, your body practices circulation and increases the functions of your organs as you practice breathing techniques.

 

Sleep Better

Yoga is also great for those who have problems with sleeping. As yoga calms the body down through the practice of breathing and mindfulness, you’ll feel more at peace and calm after your practice. As your body is relaxed, you will be able to sleep better at night, which is essential for your health and daily function.

pexels-photo-110208

Weight and Dementia

When it comes to weight, we all know that a physical injury, emotional turmoil, a change in metabolism with age, or a sedentary lifestyle are just some of the ways that a person can go from having a BMI (Body Mass Index) in the normal range to having one in the overweight range before we even realise it. It’s not just those who make poor choices, have issues with impulse control, or are ill-educated about nutrition that can end up packing on the pounds, it can happen to any of us.

But if we stop paying attention -or never paid attention to begin with- once you have gained the weight there are serious consequences to keeping that weight on over time. Obviously there are common side-effects like diabetes and heart disease, but now there has been a study published in the journal Neurology by the American Academy of Neurology that shows gaining and keeping the weight on may actually speed up dementia or other forms of cognitive decline.

Conducted by Dr Maxime Cournot of Toulouse University Hospital in France, more than 2,000 people between the ages of 32 and 62 sat for four different cognitive tests in 1996 and then took the tests again in 2001.

Those with a BMI of 20 (which is considered to be in the healthy range) remembered an average of 9 out of 16 words in a language test, or an average of 56% of the vocabulary. Results from participants with a BMI of 30 (in the range of obese) remembered 7 out of 16 words on average, or only 44% of the vocabulary. The majority of the participants who gained weight between the first and second rounds of tests did not show much change in cognitive function, but those who had a high BMI before the first test and kept the weight on in the years between the first and second test showed higher levels of what Dr Cournot described as “cognitive decline”.

According to the World Health Organisation, BMI is calculated by multiplying your height in meters by itself, and then dividing your weight in kilogrammes by the value calculated by doubling your height. A BMI of 18.5 or less is considered underweight. Normal ranges from 18.5 to 24.9, overweight from 25 to 29.9, and obese is BMI 30.0 and above. While there are some limitations to body mass index calculations, and the method has received some criticism, it is the still the only accessible and consistent tool in use for physicians.
While this research is new and shows correlation rather than causation, and more research needs to be conducted, there are several hypotheses put forward by Dr. Cournot as to the potential cause of these findings. One being that the hormones secreted from fats could have a damaging effect on cerebral cells, resulting in decreased brain function. She also mentioned that insulin resistance could have some connection to lessened cognitive activity. “Another explanation could be that since obesity is a widely known cardiovascular risk factor, due to the thickening and hardening of the blood vessels, that the same happens with the arteries in the brain,” she said.

clinic-doctor-health-hospital

The Global Problem of Health Epidemics

The Global Problem of Health Epidemics

Rapid identification and control of emerging infectious diseases helps promote health around the world, as well as contain and prevent the international spread of disease, while minimizing interruption of world travel and trade.

The fact is that the frequency of health problems and epidemics all over the world are becoming alarming. With the resurgence of Ebola, Tuberculosis in India and now the threat of outbreak of Zika virus in the Philippines, it seems like when one problem is resolved, there comes another one that threatens not only health but other sectors of the country. The only way to resolve this is with global governance, because without governments and organizations like the WHO (World Health Organization) and the CDC (Center for Disease Control) working in conjunction with scientists worldwide, the spread of epidemics often happens too quickly for one country alone to contain and treat. Outside of the current global health crises, we have seen the rapid spread of the 2003 SARS epidemic, and the 2009 spread of novel H1N1 influenza in recent history.

On that note, the countries and agencies all over the world including WHO and United Nations (UN) developed a way to help each other by establishing the Sustainable Development Goals to frame what actions and policies will be implemented to achieve each of the goals. It was September 25th, 2015 when countries around the world set the new Sustainable Development Agenda, also known as the 2030 Agenda for Sustainable Development, aimed to end poverty, to protect the Earth and to ensure the prosperity for everyone in this planet.

For these goals to be achieved, it is imperative that everyone involved including the governments, civil society, private sector and ordinary people to do their part. You probably think that there is nothing you can help to help achieve these goals, but that is not true. You can have as much contribution as the other sectors on realizing these sustainable development goals.

How You Can Help in Achieving the Global Goals

No matter where you are or what you do, there are simple things that you can to help achieve these goals. In your simple effort, you can free your country and this world from poverty, inequalities and injustices slowly but surely. How so? First, you need to get informed about the Sustainable Development Goals.

Get as much information you can from the website that explains all the simple details of the Global Goals to get a clear context of the goals. When you learn of the details, then you can begin to educate your families, friends and colleagues about the goals. Additionally, you need to explore the realities of achieving the goals as even though it all seems so simple, it is not.

One of the most effective ways you can help in achieving the goals is by lending your skills and time. This is because most agencies that can help lack the right skills and that’s where you come in. If you can lend a bit of your time and skills to help them, it will help them improve and speed up their work and produce a significant impact in building a truly better world.

1

Seniors & Exercise, How Long, How Often, How Much?

We all know that fitness is one of the major keys to staying active, healthy, happy, and full of vitality as you age. But seniors also need to take into account that injury from overexertion or exercise too strenuous can lead to serious complications or much longer healing times as you age.

A large health study suggests that the elderly can benefit from as little as 15 minutes per day of moderately heart-pumping exercise. (Though 30 minutes minimum is recommended.) An active fitness routine can help everything from balance and strength, to delaying the onset of heart disease and dementia. It can reduce depression, prevent diabetes, delay or prevent osteoporosis, and reduce occurrences of breast and colon cancer.

So what kind of exercise should you do? For how long? And how often?

There are three main types of exercise, aerobic/endurance-building, weight training, and stretching.

Endurance building exercises are activities like walking, swimming, dancing, or anything else that gets your heart rate up and increases circulation falls into this category. This includes chores like shovelling snow, walking the dog, raking leaves, or mowing the lawn, as long as you do it at a pace that gets your heart pumping! Increased activity that ups your heart-rate is the number one most important element for mood, weight, and cardiac benefits.

Weight training doesn’t need to mean lifting weights like a bodybuilder, although lifting weights is really good for muscle health and can counteract the muscle loss that comes along with old age. It also ups your metabolism, which helps keep your weight and blood sugar in check! Physical labour chores can be part of a weight-building regimen, as can exercise that uses your own body-weight, like push-ups, lunges, arm-circles, and sit-ups. Yoga and pilates are great ways to incorporate muscle-building into your routine.

Stretching exercises help maintain flexibility, increase balance, and help prevent injury. It’s important to include stretching with any exercise you do, because it helps prevent you from over-exerting muscles during exercise. They can also help with old injuries, back pain, headaches, and other recurring symptoms. Stretching will keep you active, reduce tension, and keep your mobility at it’s peak!

The length of time you devote to fitness daily will depend -at first- on your current fitness level. For moderate activity (working hard enough that it’s difficult to talk, but not so hard that it’s impossible), the ideal is a 30 minute workout. But consistency is more important than overworking yourself, so if you haven’t been very active until now, you might want to build up to 30 minutes over time, start with as little as 5 minutes, if you need too. Listen to your body!

A large health study in Taiwan followed about 416,000 people for an average of eight years and discovered that people who exercised just 15 minutes a day reduced their mortality from all causes by 14 per cent and increased their life expectancy by three years.

The frequency of exercise is your key to seeing long-term health benefits, so you should be trying to get some activity into your routine every day, or nearly every day. Consistency is the key to building stamina, muscle, and seeing those great health benefits.

At least twice a week your schedule should include muscle-building, and every other day should include aerobic activity. Stretching is best if it happens as part of your cool-down after working out, or first thing every morning. If 30 minutes every day doesn’t fit into your schedule, you can try dividing your time up differently, such as doing an hour and fourty-five minutes of activity every Saturday and Sunday and none during the week. Also keep in mind that 30 minutes a day can happen in three 10-minute installments, or two 15-minute sessions, if you’re busy or worried about overworking yourself.

However you set your goals, make sure you can accomplish them, and remember to always take a break if you need one! A few days off every week to relax and recuperate is better than doing damage by pushing too hard, and it’s also better than setting yourself goals that you won’t follow through on. Any activity is better than none!

Vigorous exercise carries risks that people should discuss with a doctor. You should always check with your doctor before starting a new exercise programme, especially if you have any of the following risk factors:

  • A symptom you have never told your doctor about
  • Arthritis of the hips or knees
  • Blood clots
  • Chest pain
  • Chronic lung disease
  • Diabetes
  • Eye injury or recent eye surgery
  • Family history of a cardiovascular disease
  • Foot or ankle sores that won’t heal
  • Heart disease
  • Heart palpitations
  • Hernia
  • High blood pressure
  • History of smoking
  • Infections
  • Joint swelling
  • Obesity
  • Pain or trouble walking after a fall
  • Shortness of breath
pexels-photo-59519

How to Travel for Business Without Getting Exhausted

Exhaustion, stress, and lack of sleep increase the effects of aging. For those who travel professionally, these are exactly the obstacles you routinely face. You need to be sure that you have taken some steps to travel without getting worn out every time you go somewhere. Travelling can be hard on you, but there is no reason to make it even harder. Anyone who does international travel, business travel or local travel should follow these tips so that they can get where they need to go without feeling like they are falling apart.

The first step is making sure that you are ready to go on every trip. It makes more sense to get yourself ready in advance so that you can travel. Do not pack at the last minute and expect everything to go the way that it should go. You have to be ready long before the trip, and you need to walk out the door knowing you have everything. If you travel for work frequently, consider making a standard travel checklist and using it every time as a packing guide.

Stop checking bags. It costs money, wastes time, and lengthens your trip. You want to get on and off the plane without any problem, and you want to have everything on your person the whole time, so you never worry about important clothing, documents, or equipment getting lost. Extra luggage is very hard to deal with, not just in the airport, but the hotel, taxis, or subways/buses will all mean wrangling luggage, and it will feel like you have no time on your trips because you spend it all dealing with luggage. Not to mention the time saved in packing and unpacking!

Sleep is vital for international and business travellers. Jet lag will always find you, but sleeping on planes will help keep the side-effects down. Make sure you are comfortable on your trips. International travel, business travel, and any other kind of travel has to be comfortable in order to relax or rest. Bring a pillow you really like, or try to get the right weight blanket that will help you stay warm in the conditioned air or planes and trains without overheating you. Anything that makes you more comfortable will be a good step in the right direction. Look up your plane model to help decide seating that will give you the space/location you prefer. Does noise bother you? Invest in earplugs or noise cancelling headphones. If you aren’t comfortable, you’ll either sleep lightly and get no rest, or never be able to relax at all.

Plan for unexpected things to happen on your trip. You need to be ready to adjust mentally when you get to places to do your work, and you need to be ready for anything to fail at any time. It could be a flight getting cancelled, or it could be technical failure in the conference room you are presenting in. There are just so many things that could go wrong when you are out of town, it’s a good idea to be in the mindset, and to have backup plans in place. Assuming your trip will be perfect is a recipe for stress, rather than productivity.

Travelling can be exhausting, and if you do it often it can get lonely. Staying in touch with people you care about can make travel much easier. Having someone to talk to goes a long way, and it will help you make sure that you have some place to vent when things do not go well. You can relax a lot more when you have a personal connection, and feel more at home. This person could be friend, family, co-worker, or even a friend online that travels for work as well. This method helps you keep from feeling like you life has been turned upside down every time you travel.

medic-hospital-laboratory-medical-40559

Global Population Ageing Means Singapore needs 30,000 More Health Workers

First, the good news. As we progress through the 21st century, gains in nutrition, medicine, and health mean that human beings are living far longer than ever before. This means that as we continue to advance into the 21st century, more and more health workers specialising in geriatric care will be needed. Why? Because despite the fact that so many people are now living well into their senior years, not enough are doing so with vitality. Living more years unfortunately does not translate into healthy ageing for everybody. Longer living means living with chronic illnesses, dementia, and disability created by the loss of mobility, vision, and hearing. These issues will in turn lead to increased expenses and strain on existing support services.

These concerns about an upcoming epidemic of senior health problems aren’t only going to be affecting certain parts of the world. Singapore will also be experiencing this senior health crunch, and residents of all ages may be exposed to it in less than a decade. At the National Seminar on Productivity in Healthcare earlier this month, keynote speaker Health Minister Gan Kim Yong warned that in order to insure healthy aging for its elder population, Singapore needs to see an influx of 30,000 healthcare workers over the next three years. Specialists in geriatric medicine and nurses with experience in supervising clinics will especially be in demand.

Singapore has built six new health care clinics to accommodate this need for increased medical care, and in addition to creating bed space in public hospitals for thousands of new patients, it’s estimated that almost 10,000 more patients will be seeking treatment at smaller community hospitals and nursing homes. Almost another 8,000 Singapore residents will be seeking care within their homes and day-use facilities. And in addition to a need for specialists to facilitate healthy ageing, the demand for specialists in palliative (end of life) care is expected to be on the rise as well.

While this would seem like a wonderful opportunity out there for students and health care workers in other positions, Singapore’s labour market is already experiencing a shortage of qualified workers to insure the continuing vitality of Singapore’s ageing population. And as elsewhere in the developed world, household sizes are shrinking, meaning that there will be fewer family members to assist with elder care. To combat this, Gan indicated that the government would be taking a “community” approach to geriatric care. For example, “assisted living programmes ” currently popular in the United States and Europe will be expanded in Singapore. With assisted living, seniors are able to remain in their own homes and live independently, with help from relatives and caregivers. Research shows that seniors in such an arrangement are mentally sharper and have fewer physical health problems than those in more geriatric care settings. Gan also said current nurses nearing retirement age will be encouraged to extend working both to train new caregivers and to help seniors adjust to community living programmes .

And in addition to increased emphasis on these new initiatives, Gan said the government would place new emphasis on geriatric nursing training with new programming to accommodate these new waves of Singapore residents.

Not Just Living Longer, But Better, with Diabetes Management

diabetes-blood-sugar-diabetic-medicine-46173Intensive management of type II diabetes may make a huge difference on how long, as well as how well, you will live, according to this study. Even if you failed to manage your diabetes until beyond middle age, beginning management now could have a dramatic impact on your longevity and quality of life with the disease, the research reports.

People who were at risk of complications associated with type II diabetes were selected randomly. They either pursued their usual treatment or were put in a group treated with multi-pronged and aggressive treatment programme. Two decades after the start of the research, the scientists have discovered that people involved in an aggressive treatment team lived nearly 8 years longer. Additionally, they lived much better and their risk of kidney disease, heart disease, and blindness dropped significantly. The only complication which does not improve is nerve damage triggered by diabetes, which is permanent.

Early and intensified intervention of patients diagnosed with type II diabetes, treated with microalbuminuria, together with a target driven pharmacological medicine regime and some behavioural actions are the course of treatments that showed the results of a lengthened life span. Not only that, but the additional lifespan will be relatively free from serious or feared complications. It was confirmed by Dr. Oluf Pedersen, who specialises in endocrinology and internal medicine at the Novo Nordisk Foundation Centre for Basic Metabolic Research at the University of Copenhagen, which is situated in Denmark.

Microalbuminuria is the term pertaining to an amount of protein in your urine. Protein in the urine is a sign which means the kidneys are not working properly, and it is also the initial symptom of diabetic kidney injury according to ADA or American Diabetes Association.

Somebody with this condition is likely to develop some other complications associated with diabetes since it’s the marker for general blood vessel damage, as explained by Pedersen. Their average age was around 55 at the beginning of the research, which started in 1993. Everyone was overweight, bordering on obesity, according to the data that was collected at the outset of the study. Pedersen mentioned that the objective of intensive treatment is to resolve all changeable risk factors for early death and complications. Such factors involve blood sugar, cholesterol, blood pressure and triglycerides as well as the danger of blood clots.

If appropriate, medicines like cholesterol-lowering statin or drugs for hypertension were prescribed. Behaviour modification was a crucial aspect of intensive treatment. The study volunteers are instructed on making exercise and healthy diet changes. They were given help in order to stop smoking. The patients were cured at Steno Diabetes Centre located in Copenhagen for nearly 8 years. They were consistently motivated and educated, according to the staff. All of this motivation, clearly, has been paid off.

The blood pressure of the patients dropped. Their good cholesterol level went up, while the bad ones -as well as the triglycerides- also dropped. After more than twenty years, 38 of the people who participated in the group that underwent intensive treatment died, versus the 55 people who were in the traditional treatment group. Aside from longer survival, this intensive group got an average 8-year delay with the onset of heart disease and stroke.

The benefits were so clear following the ending of the intensive treatment that both of the two groups,  the intensive and traditional treatment alike, got the chance to continue the intensive treatment if they wanted to!

Dr. Joel Zonszein is director of the Clinical Diabetes Centre at Montefiore Medical Centre in New York City. “These results are impressive, and the message is important. Physicians are not being aggressive enough, and aren’t treating to targets at the beginning,” he said. “If you look at all the factors they (the Danish researchers) treated, about 80 per cent of the U.S. population isn’t treated correctly, according to national surveys,” said Zonszein, who wasn’t involved with the study.

Keeping Your Brain Agile with Music

pexels-photo-144026You may not be considered one of the professional performers out there. But that doesn’t mean you don’t benefit from learning the way to play musical instruments. Music will always be an exciting and enthralling experience, and later on, you will realise that playing it is a great mental workout.

Even more specifically, learning a musical instrument can improve mental function in the elderly, and prevent cognitive decline.

A great example here is Keith Richards, who is still often seen performing despite his advancing age. He is among those who have survived a rock n roll lifestyle, drugs and alcohol, and is still vital, passionate, and performing at the age of seventy-three. The impressive thing is that he still prances around onstage and holds his own with other artists who are much younger.

It is no mystery why artists like Keith Richards are heading to the road of healthy aging. And he’s not the only one: Bo Diddly played the blues until he was seventy-eight. It’s associated with the fact that they give their brains a fantastic workout by way of playing a musical instrument. Learning and playing a musical instrument is considered by neuroscientists as something that is incredibly beneficial at any age. It causes a symphony of neural fireworks, and is one of the best things you can do for your brain: “People with more musical training responded faster than those with little or no training, with no loss in accuracy. “This result suggests that higher levels of musical training might result in more efficient information processing in general,” the researchers write. In addition, “higher levels of musical practise were also associated with a better engagement of cognitive control processes, as indicated by more efficient error and conflict detection,” the researchers report. Participants who had spent more quality time with their instruments had “a better ability to detect errors and conflicts, and a reduced reactiveness to these detected problems.”

According to research, the midline structure called corpus callosum connects both sides of the brain and integrates the sensory, cognitive information, and motor skills between the cerebral hemispheres. This area has been found to be bigger in most musicians.

Neuroscientists also suggest learning musical instruments in bolstering and exercising the brain, which provides limitless pro-age health benefits. Some may have felt the urge to play the guitar or piano as they grew older. This might not just be wishful thinking, it may actually be due to the neural networks in the brain, begging them to find a way to activate it again. Through learning a new instrument, one can activate neurons that are hard to activate elsewhere in life, helping to keep the pathways in the brain healthy and connected.

Healthy ageing research suggests that wellness is linked to the brain, and a healthy brain can add years to life, even without other changes. It is through experience and education that people develop a refined neural network in the brain, and by activating the networks with lessons, and keeping them maintained or even developing them further via practise, the brain can keep performing well.

The old adage still remains true today, “use it or lose it”. This is just as much true of the brain as anywhere else. Neural pathways that go unused begin to decline, leading to degeneration, cognitive impairment, or dementia.

Even if it’s after your retirement, it’s not too late! You can still make significant progress, and derive intense satisfaction and pleasure from it. More effort will be involved, as learning new things doesn’t happen quickly or easily, just like in the early years in life. That is exactly what makes it more meaningful and more challenging. For vitality and brain agility, turn your attention to musical instruments!

Consortium Uses Tiny Worms To Screen For Anti-Aging Chemicals

Caenorhabditis_elegans_hermaphrodite_adult-en.svgThere is currently a large need for pharmaceuticals that can combat age-related diseases such as Alzheimer’s disease, cancer, and Huntington’s disease. Doctors at the Buck Institute for Research on Aging are trying to fill this niche. The team is working to identify chemicals that can improve lifespan in a number of organisms. These chemicals may one day become incorporated in an anti-aging drug in the future.

The Buck Institute’s researchers are working with teams led by Monica Driscoll, Ph.D. at Rutgers University, and Patrick Phillip, Ph.D., at the University of Oregon. The team is working together in the Caenorhabditis Intervention Testing Programme (CITP), a consortium funded by the National Institute on Aging. Researchers in the consortium are using a number of strains and species of the roundworm Caenorhabditis to find chemical agents that can delay aging effects across a number of organisms with varied genetic backgrounds.

The processes associated with aging are very complex and are most likely informed by an individual’s genes. CITP hopes that if scientists can detect agents that show effects in a variety of organisms with different genetic backgrounds, those agents may have a high likelihood of being effective in humans, too. Roundworms are ideal for screening chemicals affecting lifespan in a short amount of time because they only live about three weeks.

Researchers at the Buck Institute used three stains each of the roundworms C. briggsae and C. elegans in order to test a series of ten compounds that have shown increased longevity in other organisms such as C. elegans. Most of the chemicals that had been previously studied were shown to extend lifespan in the laboratory-adapted N2 strain of C. elegans. The researchers did not yet know how these chemicals would behave in wild strains of C. elegans or C. briggsae.

The research showed that a number of the compounds did increase longevity in the C. elegans strains, while others only showed these effects in the N2 C. elegans strain. However, the compound Thioflavin T lengthened lifespan in every organism tested. It was also extremely potent, with at least one of the strains consistently showing a doubling of lifespan.

Thioflavin T is a dye that is commonly used in laboratories. It binds to toxic protein aggregates called amyloid plaques. These plaques are found in the brains of people who have Alzheimer’s disease. Buck Institute researchers had previously published results stating that the lifespan of one strain of C. elegans could be extended by Thioflavin T. The study also stated that Thioflavin T is likely to work by allowing the organisms to maintain proper transport, folding, expression, and clearance of proteins.

The CITP has created a stronger scientific process by bringing together multiple institutions and allowing these researchers to validate each other’s work. The Buck Institute team recently analysed the results as a whole and found the the three CITP study sites did a good job of reproducing each other’s data. However, analysis of the individual experiments at any given site shows that there is high variation from experiment to experiment. The experiments still need to be replicated in a large variety of organisms to ensure the anti-aging effects of these chemicals.

According to lead author Mark Lucanic, Ph.D., the researchers hope that the chemicals that have promising effects can be tested in vertebrates in the future. If the chemicals are effective in vertebrates, they may be the basis of drugs that can combat age-related illnesses in humans. This could be a huge step for anti-aging and the prevention of diseases associated with aging.

Page 1 of 2

Powered by WordPress & Theme by Anders Norén